| Lub npe lag luam | UniAPI-PBS |
| CAS | 1405-20-5 : kuv |
| Khoom npe | Polymyxin B sulfate |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov |
| Solubility | Dej soluble |
| Daim ntawv thov | Tshuaj kho mob |
| Assay | Cov txiaj ntsig ntawm polymyxin B1, B2, B3 thiab B1-I: 80.0% minPolymyxin B3: 6.0% maxPolymyxin B1-I: 15.0% max |
| Pob | 1kg net rau txhuas tau |
| Txee lub neej | 2 xyoo |
| Cia | Khaws rau hauv qhov chaw txias thiab qhuav, deb ntawm lub teeb. 2 ~ 8 ℃ rau cia. |
| Chemical Structure |  |
Daim ntawv thov
Polyxin B sulfate yog cationic surfactant tshuaj tua kab mob, sib xyaw ntawm polyxin B1 thiab B2, uas tuaj yeem txhim kho permeability ntawm cell membrane. Yuav luag tsis muaj ntxhiab tsw. Sensitive rau lub teeb. Hygroscopic. Soluble hauv dej, me ntsis soluble hauv ethanol.
Clinical nyhuv
Nws cov tshuaj tua kab mob spectrum thiab daim ntawv thov kev kho mob zoo ib yam li polymyxin e. Nws muaj inhibitory los yog bactericidal teebmeem ntawm Gram-tsis zoo cov kab mob, xws li Escherichia coli, Pseudomonas aeruginosa, paraescherichia coli, Klebsiella pneumoniae, acidophilus, pertussis thiab dysentery. Clinically, nws yog tsuas yog siv rau kev kis kab mob los ntawm cov kab mob rhiab heev, urinary system kis los ntawm Pseudomonas aeruginosa, qhov muag, trachea, meningitis, sepsis, hlawv kab mob, daim tawv nqaij thiab mucous daim nyias nyias, thiab lwm yam.
pharmacological kev txiav txim
Nws muaj cov nyhuv antibacterial ntawm Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Haemophilus, enterobacter, Salmonella, Shigella, pertussis, pasteurella thiab Vibrio. Proteus, Neisseria, Serratia, pruvidens, kab mob Gram-positive thiab obligate anaerobes tsis rhiab rau cov tshuaj no. Muaj kev tawm tsam ntawm cov tshuaj no thiab polymyxin E, tab sis tsis muaj qhov sib txawv ntawm cov tshuaj no thiab lwm yam tshuaj tua kab mob.
Nws yog tsuas yog siv rau qhov txhab, tso zis, qhov muag, pob ntseg, trachea kab mob tshwm sim los ntawm Pseudomonas aeruginosa thiab lwm yam Pseudomonas. Nws kuj tseem siv tau rau sepsis thiab peritonitis.
