RJMPDRN®REC sawv cev rau kev nce qib tseem ceeb hauv cov khoom xyaw nucleic acid-based cosmetic, muab cov ntses salmon recombinant PDRN uas tau tsim los ntawm biotechnology. PDRN ib txwm muaj feem ntau yog rho tawm los ntawm ntses salmon, ib qho txheej txheem uas raug txwv los ntawm cov nqi siab, kev hloov pauv ntawm ib pawg mus rau ib pawg, thiab kev huv huv tsawg. Ntxiv mus, kev vam khom rau cov peev txheej ntuj tsim kev txhawj xeeb txog kev ruaj khov ntawm ib puag ncig thiab txwv kev nthuav dav kom tau raws li qhov kev thov ntawm kev lag luam.
RJMPDRN®REC daws cov teeb meem no los ntawm kev siv cov kab mob tsim los ua kom rov ua dua cov khoom PDRN, ua kom muaj kev tswj hwm kev tsim khoom thaum tswj hwm qhov zoo rov ua dua thiab txo qis kev cuam tshuam rau ecological.
Txoj kev sib xyaw ua ke no tso cai rau kev tsim cov kab ke ua haujlwm kom meej, ua rau cov khoom nucleic acid tsim rau cov teebmeem bioactive tshwj xeeb. Qhov hnyav molecular thiab kev sib xws ntawm cov khoom seem raug tswj hwm nruj me ntsis, txhim kho ob qho tib si uniformity thiab nkag mus rau hauv daim tawv nqaij. Raws li cov khoom xyaw tsis muaj tsiaj, RJMPDRN®REC ua raws li cov qauv kev cai lij choj thoob ntiaj teb, nthuav kev lees txais ntawm kev ua lag luam hauv cov cheeb tsam rhiab heev. Cov txheej txheem tsim khoom ua raws li cov qauv zoo nruj, siv cov txheej txheem fermentation thiab purification uas ua rau muaj qhov zoo sib xws, purity siab, thiab kev muab khoom txhim khu kev qha - daws cov nqi, cov khoom xa tuaj, thiab cov teeb meem ib puag ncig ntawm kev rho tawm ib txwm muaj.
Physicochemically, RJMPDRN®REC yog ib hom hmoov dawb, yaj tau hauv dej uas muaj DNA nrog RNA me me, los ntawm cov kab ke PDRN ntses salmon, thiab muaj pH ntawm 5.0–9.0. Nws yog ib yam khoom xyaw zoo nkauj uas siv tau rau hauv cov tshuaj pleev ib ce zoo nkauj, tshuaj pleev, tshuaj pleev qhov muag, tshuaj npog qhov ncauj, thiab lwm yam tshuaj pleev rau daim tawv nqaij zoo. Kev tshawb fawb hauv vitro tau ua pov thawj tias nws muaj kev nyab xeeb thiab ua tau zoo ntawm 100–200 μg/mL, txhawb nqa kev loj hlob ntawm cov cell thiab kev ua haujlwm tiv thaiv kev o yam tsis muaj cytotoxicity.
Cov kev tshawb fawb txog kev ua haujlwm tau zoo ntxiv qhia txog kev ua haujlwm zoo tshaj plaws ntawm RJMPDRN®REC. Nws ua rau cov fibroblast migration zoo dua, ua tiav qhov kev loj hlob ntawm 131% ntawm 41 teev piv rau cov kev tswj. Hauv cov nqe lus ntawm collagen synthesis, RJMPDRN®REC txhawb nqa tib neeg hom I collagen los ntawm 1.5 zaug thiab hom III collagen los ntawm 1.1 zaug piv rau cov kev tswj, ua tau zoo dua li cov PDRN uas tau los ntawm ntses salmon. Tsis tas li ntawd, nws tiv thaiv cov neeg mob o xws li TNF-α thiab IL-6. Thaum ua ke nrog sodium hyaluronate, , RJMPDRN®REC ua rau pom cov teebmeem synergistic, ua rau cov cell tsiv teb tsaws chaw ntau ntxiv, qhia txog lub peev xwm muaj zog rau kev sib koom tes hauv kev kho dua tshiab thiab tiv thaiv kev laus ntawm daim tawv nqaij.
Hauv kev xaus, RJMPDRN®REC qhia txog kev siv thev naus laus zis los ntawm kev rho tawm ib txwm mus rau kev tsim cov khoom siv biotechnological, muab kev rov ua dua tshiab, huv si, thiab kev xaiv ruaj khov rau cov tshuaj pleev ib ce zoo tshaj plaws. Nws cov bioactivity, kev nyab xeeb profile, thiab scalability tso nws ua cov khoom xyaw tseem ceeb rau cov khoom siv pleev ib ce uas tsom mus rau kev tiv thaiv kev laus, kho tawv nqaij, thiab kev noj qab haus huv ntawm daim tawv nqaij, ua raws li qhov kev thov hloov pauv rau cov khoom xyaw pleev ib ce ruaj khov thiab tau lees paub los ntawm kev tshawb fawb.
Nyem qhov no kom paub ntxiv txog cov khoom no.
Lub sijhawm tshaj tawm: Lub Yim Hli-28-2025