Lub tswv yim raw khoom tsim

Molecular self-assembly

--a frontier ntsuab chemistry yam tsis muaj daim ntawv cog lus tawg thiab kev sib txuas

Lub hauv paus ntsiab lus ntawm molecular self-assembly:

1. Zoo li nyiam nyiam - tsav cov khoom zoo sib xws los sib sau ua ke thiab sib koom ua ke, thiab cov khoom siv nrog cov khoom sib txuas kom nyiam ib leeg.

2. Lub zog qis tshaj plaws—kev txav mus los ntawm cov khoom thiab tus cwj pwm molecular yuav mus rau qhov ruaj khov tshaj plaws. Nws yog ib txoj hauv kev rau cov pab pawg molecular kom raug teeb tsa rau hauv cov qauv siab heev.

Molecular self-assembly-designability, CP qauv ntawm molecules tuaj yeem txhim kho kev ua haujlwm lom neeg:

1. Txhua lub molecule muaj nws cov qauv tshwj xeeb thiab kev ua haujlwm zoo, thiab nws yog qhov nyuaj rau kev ua tiav kev sib koom ua ke thiab kev kho kom meej raws li kev sib xyaw dawb ntawm cov qauv tsim.

2. Tseem muaj ntau cov molecules uas muaj kev ua haujlwm lom neeg zoo heev uas tau txwv tsis pub lawv nqus thiab siv vim lawv cov yam ntxwv tsis zoo.

3. Cov tshuaj ntsuab uas siv hauv tshuaj suav suav yog hais txog "tus huab tais, cov nom tswv thiab cov neeg pab", es tsis yog hais txog ntau yam zoo dua.

Cov txheej txheem kev hloov kho thiab kev ua kom zoo dua ntawm cov qauv supramolecular:

1. Kev tshuaj ntsuam xyuas lub computer-pab tau zoo rau kev tshuaj xyuas sai ntawm cov khoom tsim nyog los ntawm Cambridge Crystal Data Center.

2. Siv kev ua haujlwm nrawm rau txoj kev kawm cov qauv supramolecular thiab txiav txim siab tias hom supramolecular yog qhov tsim qauv.

3. Los ntawm kev txheeb xyuas cov kev mob tshwm sim thiab qhov nyuaj, cov qauv supramolecular tau ua kom zoo dua.

4. Kev suav ntawm ntau yam khoom ntawm supramolecules, suav nrog cov khoom siv hluav taws xob, kho qhov muag thiab thermodynamic.

5. Kev suav cov khoom spectral xws li molecular spectrum thiab lub zog spectrum.

6.Los ntawm molecular docking thev naus laus zis, qhov chaw sib cuam tshuam ntawm supramolecular raw cov ntaub ntawv thiab lub hom phiaj cov protein tau kwv yees, thiab kev sib cuam tshuam ntawm cov molecules tau piav qhia hauv qhov tob.

Supramolecular eutectic / Ionic ntsev tshuab

Technical nta: kev lag luam thawj zaug, tshuaj xyuas qhov zoo tshaj plaws CP Cheebtsam ntawm active Cheebtsam rau eutectic ntxiv dag zog rau

Qhov zoo: txo cov khaus khaus, txhim kho solubility, txhim kho functionality, txhawb permeability, txhim kho stability

Piv txwv ntawm cov khoom xyaw: salicylic acid, uric acid, ferulic acid, glycyrrhizic acid, adenosine, niacinamide, 4MSK

Cov khoom xyaw ntuj tsim los ntawm cov ntawv teev npe ntawm cov khoom siv tshuaj pleev ib ce, tom qab kev kuaj xyuas xws li quantum chemical simulation, high-throughput screening, Gaussian optimization, KingDraw, MestReNova, FTIR, thiab NMR, cov khoom tau txais zoo heev peb-dimensional siv lead ua qauv, zoo stability, siab purity, tsawg impurities. Nws tuaj yeem daws qhov mob ntawm daim ntawv thov cov ntsiab lus ntawm cov khoom xyaw ua haujlwm hauv cov zaub mov, tshuaj thiab tshuaj pleev ib ce, thiab txhim kho bioavailability thiab kev nyab xeeb ntawm cov khoom xyaw ua haujlwm.

Supramolecular kev ua haujlwm extraction technology

echnical nta: Kev lag luam thawj zaug, kev sib xyaw ntawm molecular imprinting thev naus laus zis thiab ntuj supramolecular cov kuab tshuaj, muaj txiaj ntsig zoo ntawm cov khoom xyaw cog qoob loo

Qhov zoo: Lub hom phiaj extraction, cov extraction efficiency yog nce 5 npaug piv nrog cawv extraction, thiab dej extraction yog nce 20 zaug; tsis muaj kev sib cais, txo nqi, Kev nkag mus-txhawb cov khoom xyaw Piv txwv li: txiv ntseej (oleuropein, hydroxytyrosol), rhodiola, tshuaj Phyloporus, dej dawb lily, micrococcus

Ntuj sib sib zog nqus eutectic hnyav (NaDES): Nws yog thawj zaug pom los ntawm cov kws tshawb fawb hauv kev tsom xam ntawm cov nroj tsuag metabolomics. Thaum lub sij hawm qee qhov kev loj hlob ntawm cov nroj tsuag (germination, cryopreservation), cov hlwb yuav spontaneously tsim cov kua nplaum uas tsis muaj dej thiab lipids, zoo ib yam li kev sib xyaw ntawm eutectics.

Raws li niaj hnub ntsuab sib cais tshuab, kev sib xyaw membrane tshuab, ua tiav los ntawm ultrasonic / microwave li tshuab kom ua tiav qhov kub thiab txias, tsom, siab ciency, siab zoo thiab ntsuab extraction ntawm active Cheebtsam.Los ntawm lub ntuj supramolecular hnyav raws li kev ua tau zoo extraction hnyav, nws daws tau ntau yam teeb meem xws li tsis tshua muaj efficiency, siab nqi thiab teeb meem nyob rau hauv pov tseg kua tshuaj daws tau cov tshuaj ramolecular extract. lawv kev ua tau zoo. Cov tshuaj supramolecular hnyav uas tau xaiv muaj kev ua haujlwm ruaj khov thiab txhim khu kev ua haujlwm zoo ntawm cov khoom xyaw nquag, thiab cov khoom siv extraction tuaj yeem nce ntxiv los ntawm 20 npaug.

Supramolecular synergistic penetration technology

Technical nta: Kev lag luam thawj zaug, los ntawm supramolecular hnyav synergistically txhawb kev nkag mus ntawm macromolecules / dej-soluble / nyuaj rau nqus cov khoom xyaw

Cov txiaj ntsig zoo: txhim kho kev ruaj ntseg, tsis muaj kev puas tsuaj thiab muaj txiaj ntsig zoo dua, kev sib koom ua ke, kev coj ua kom muaj txiaj ntsig hauv dermis, thiab bioavailability nce 5-7 zaug Cov khoom xyaw piv txwv: collagen, Bosein, xiav tooj liab peptide, hexapeptide, compound peptide, β-glucan.

Txij li thaum qhov hnyav molecular ntawm peptide tseem loj dua piv rau lwm cov khoom xyaw nquag, cov tawv nqaij nkag mus rau qhov qis. Qee qhov kev nkag mus-txhim kho txoj kev xav tau los txhim kho qhov kev nkag mus-txhim kho qhov nqus ntawm peptide, thiaj li ua tiav cov concentration qis thiab kev ua haujlwm siab, thiab ua tiav kev tiv thaiv kev laus zoo dua.

Nyob rau hauv kev teb rau kev lag luam mob taw tes ntawm kev nkag mus tsis zoo, siab hydrophilicity thiab tsis tshua muaj bioavailability ntawm cov tsoos macromolecules, JUNAS Lub sij hawm Particle khoom synthesis ntawm quantum chemistry pab, tuaj yeem ncaj qha mus txog cov epidermis thiab dermis ntawm daim tawv nqaij los ntawm trans-cellular, intercellular thiab follicular hws ducts. Tsis muaj kev puas tsuaj rau daim tawv nqaij qauv.Lub bioavailability ntawm cov khoom yog nce los ntawm 5 lub sij hawm, nrog rau ntau tshaj 45% nyob rau hauv lub dermis, tsis muaj kev puas tsuaj rau daim tawv nqaij qauv.Qhov kev nkag mus rau hauv cov nyhuv thiab nyob rau hauv lub sij hawm tau ua tiav lub ntsiab tseem ceeb ntawm kev txhim kho.Qhov no yog thawj zaug ntawm nws hom nyob rau hauv kev lag luam.

Supramolecular biocatalysis technology

Bioenzyme-directed catalysis: supramolecular cov kuab tshuaj yog siv los ua cov substrates los txhim kho kev ua haujlwm enzyme, txhim kho chiral xaiv, thiab ua tiav siab purity

Engineering fennel ntsuab fermentation: xaiv cov nroj tsuag yam ntxwv, txhim khu cov ntsiab lus ntawm cov khoom xyaw nquag, cov mis tsis muaj dej, txhim kho tag nrho cov txiaj ntsig

Rov qab micellar fermentation thev naus laus zis: tshuaj xyuas cov yam ntxwv ntawm hom, fermenting zaub roj, muaj txiaj ntsig ntau dua, txhim kho daim tawv nqaij thiab txhawb kev nqus.

Raws li recombinant gene technology, ib-kauj ruam gene cloning technology thiab high-density bioenzyme catalytic technology, genetically engineered cov kab mob yog siv raws li catalytic carriers kom paub qhov loj-scale zus tau tej cov active tshuaj:

Nyob rau hauv lub supramolecular hnyav system, lub enzyme qhia ntau dua kev ua si, xaiv thiab stability, siab siv ntawm substrate raw cov ntaub ntawv, tsawg muaj kuab paug nyob rau hauv cov txheej txheem ntau lawm, me me tshuaj tiv thaiv tej yam kev mob, muaj kev ruaj ntseg kev ua tau zoo thiab ntau lawm.

Rov qab micelle fermentation technology:

xaiv natural oils nrog Suav yam ntxwv lP yog spontaneously tsim los tsim surfactants nyob rau hauv qhov kev txiav txim ntawm genetically engineered bacteria.lt yog sib sau ua ke raws li cov cab kuj ntawm anti-micellar bundle kom paub txog cov anti-micellar bundle wrapping ntawm dej-soluble active cov khoom xyaw kom ua tau nplua nuj daim ntawv thov scenarios, qhov kawg ntawm daim tawv nqaij kev paub, thiab efficacy.

Supramolecular microencapsulation technology

Cov yam ntxwv nta: liposome encapsulation, tsom tso tawm ntawm cov dermal hlwb, tsom tso tawm ntawm cov hauv paus plaub hau, thiab teb cov lus tso tawm ntawm cov kab mob inflammatory

Qhov zoo: Nanoization, kev xa khoom zoo, kev tso tawm ntev ntev, txo qhov khaus, txhim kho kev ruaj ntseg, thiab txhawb kev permeability

Piv txwv ntawm cov khoom xyaw: astaxanthin, glabridin, vitamin A, xiav tooj liab peptide, biotin, ceramide, cog cov roj tseem ceeb

Supramolecular microencapsulation tshuab yog ua raws li liposome, roj emulsion, ionic kua stabilization tshuab, dermal cell tsom tso tawm tshuab, cov plaub hau follicle tsom tso tawm tshuab, thiab inflammatory factor responsive release technology.Los ntawm kev tsim cov khoom siv thauj khoom, cov khoom tuaj yeem xa cov khoom xyaw nquag. lt muaj qhov zoo tshaj plaws transdermal haum tus nqi, lub sijhawm nyob ntev thiab kev ruaj ntseg zoo hauv qhov chaw ntawm daim tawv nqaij. Nws kuj tseem muaj cov nqi qis thiab kev siv tau zoo hauv kev siv tshuaj pleev ib ce, khoom noj khoom haus thiab tshuaj.

Peptide hierarchical self-assembly technology

Technical nta: kev lag luam thawj zaug, tsom kev tswj hwm ntawm ntau theem qauv ntawm cov amino acid chains thiab polypeptides, self-assembled luv peptides, supramolecular polypeptides

Kev taw qhia kev: Txhim kho amphiphilicity, txhim khu kev ruaj ntseg thiab kub tsis kam, txo toxicity thiab tiv thaiv kev ntxhov siab, txhawb kev nqus, thiab sib koom ua ke

Piv txwv ntawm cov khoom xyaw: supramolecular carnosine, poov xab protein peptide

Self-assembly ntawm cov proteins thiab peptides tsis yog tsuas yog nyob rau hauv lub neej systems, tab sis kuj yog ib tug zoo heev endogenous tshuaj rau tib neeg lub cev, thiab kuj yog ib tug ntawm cov zoo txhais tau tias rau synthesizing nano-biological cov ntaub ntawv. Cov txheej txheem peptide tus kheej sib dhos yog txheej txheem hierarchical los ua ke, thiab "polar amino acid zipper qauv" yog ib hom tshiab ntawm super-secondary qauv, uas yog tsim rau hierarchical los ua ke ntawm peptides los ua ib tug txiav txim aggregates.

Kev taw qhia kev cai ntawm qhov loj ntawm luv peptides tuaj yeem ua tiav los ntawm kev hloov cov hydrophobicity thiab sab saw branching ntawm hydrophobic residues.

Raws li Shinehigh Innovation qhov tshwj xeeb ProteinDataBank (PDB) database, ua ke nrog kev soj ntsuam kev soj ntsuam, molecular dynamics thiab quantum chemistry suav los txheeb xyuas cov qauv ntawm peptide molecules, thiab tom qab ntawd phim lawv nrog high-throughput self-assembly molecules.Modulation ntawm hom kev hloov pauv ntawm cov amino acids thiab cov txheeb ze molecules. folding qauv, yog li txhim kho lub peev xwm ntawm cov molecule rau nws tus kheej-assemble.Realize lub hom phiaj kev cai ntawm peptides. Lub self-assembled peptide muaj zoo heev amphiphilicity thiab symmetry, uas zoo heev txhim kho peptide stability, transdermal muaj peev xwm thiab bioavailability.