Kev tsim cov khoom siv raw tshiab

Kev sib dhos ua ke ntawm cov molecular

--ib qho tshuaj ntsuab ntsuab uas tsis muaj kev sib txuas thiab kev sib txuas dua tshiab

Lub hauv paus ntsiab lus ntawm kev sib sau ua ke ntawm molecular:

1. Yam zoo li rub cov yam zoo li - tsav cov khoom zoo sib xws los sib sau ua ke thiab teeb tsa ib leeg, thiab cov khoom uas muaj cov yam ntxwv sib pab kom rub tau ib leeg.

2. Lub zog qis tshaj plaws—kev txav mus los ntawm cov khoom thiab tus cwj pwm molecular yuav mus rau qhov ruaj khov tshaj plaws. Nws yog ib txoj hauv kev rau cov pab pawg molecular kom raug teeb tsa rau hauv cov qauv siab heev.

Kev tsim qauv ntawm cov molecule, cov qauv CP ntawm cov molecule tuaj yeem txhim kho cov haujlwm ntawm lub cev:

1. Txhua lub molecule muaj nws cov qauv tshwj xeeb thiab cov khoom ua haujlwm, thiab nws nyuaj rau ua tiav kev sib koom ua ke thiab kev kho mob kom raug raws li kev sib xyaw dawb ntawm qib formulation.

2. Tseem muaj ntau cov molecule uas muaj kev ua haujlwm zoo heev uas tau txwv lawv qhov kev nqus thiab kev siv vim lawv cov yam ntxwv tsis zoo.

3. Cov tshuaj ntsuab uas siv hauv tshuaj suav suav yog hais txog "tus huab tais, cov nom tswv thiab cov neeg pab", es tsis yog hais txog ntau yam zoo dua.

Cov txheej txheem kev hloov kho thiab kev ua kom zoo dua ntawm cov qauv supramolecular:

1. Kev tshuaj ntsuam xyuas uas siv lub khoos phis tawj pab kom ua tau zoo rau kev tshuaj ntsuam sai ntawm cov khoom ua ntej tsim nyog los ntawm Cambridge Crystal Data Center.

2. Siv txoj kev xav txog qhov ceev ntawm cov khoom siv los kawm txog cov qauv supramolecular thiab cov khoom sib dhos uas txiav txim siab los ntawm cov zog intermolecular, thiab txiav txim siab seb hom supramolecular twg yog qhov sib txawv ntawm kev tsim.

3. Los ntawm kev tshuaj xyuas cov xwm txheej ntawm cov tshuaj tiv thaiv thiab qhov nyuaj, cov qauv supramolecular tau raug kho kom zoo.

4. Kev suav ntawm ntau yam khoom ntawm supramolecules, suav nrog cov khoom hluav taws xob, kho qhov muag thiab thermodynamic.

5. Kev suav cov khoom spectral xws li molecular spectrum thiab energy spectrum.

6. Los ntawm kev siv tshuab molecular docking, qhov chaw sib cuam tshuam ntawm cov khoom siv raw supramolecular thiab cov protein hom phiaj tau kwv yees, thiab cov txheej txheem sib cuam tshuam ntawm cov molecules tau piav qhia tob.

Kev siv tshuab ntsev Supramolecular eutectic/Ionic

Cov yam ntxwv kev siv tshuab: thawj zaug hauv kev lag luam, tshuaj xyuas cov khoom CP zoo tshaj plaws ntawm cov khoom siv nquag rau kev txhawb nqa eutectic

Cov txiaj ntsig: txo qhov khaus, txhim kho kev yaj, txhim kho kev ua haujlwm, txhawb kev permeability, txhim kho kev ruaj khov

Piv txwv ntawm cov khoom xyaw: salicylic acid, uric acid, ferulic acid, glycyrrhizic acid, adenosine, niacinamide, 4MSK

Cov khoom xyaw ntuj tsim los ntawm cov khoom siv raw khoom siv pleev kom zoo nkauj, tom qab kev kuaj xyuas xws li kev sim tshuaj quantum, kev tshuaj ntsuam xyuas siab, Gaussian optimization, KingDraw, MestReNova, FTIR, thiab NMR, cov khoom tau txais muaj cov qauv siv lead ua peb-seem zoo heev, ruaj khov zoo, ntshiab siab, tsawg dua cov khoom tsis huv. Nws tuaj yeem daws cov teeb meem ntawm kev siv cov khoom xyaw ua haujlwm hauv zaub mov, tshuaj thiab tshuaj pleev kom zoo nkauj, thiab txhim kho kev siv tau thiab kev nyab xeeb ntawm cov khoom xyaw ua haujlwm.

Kev siv tshuab rho tawm cov dej num supramolecular

Cov yam ntxwv ntawm kev siv tshuab: Kev lag luam thawj zaug, kev sib xyaw ua ke ntawm cov thev naus laus zis molecular imprinting thiab cov kuab tshuaj supramolecular ntuj, kev rho tawm cov khoom xyaw nquag ntawm cov nroj tsuag zoo

Cov Zoo: Kev rho tawm raws li lub hom phiaj, qhov ua tau zoo ntawm kev rho tawm nce 5 npaug piv rau kev rho tawm cawv, thiab kev rho tawm dej nce 20 npaug; tsis muaj kev sib cais, txo nqi, Cov khoom xyaw txhawb kev nkag mus Piv txwv li: txiv ntseej (oleuropein, hydroxytyrosol), rhodiola, tshuaj Phyloporus, paj dawb, micrococcus

Cov tshuaj eutectic tob tob (NaDES): Nws tau tshawb pom thawj zaug los ntawm cov kws tshawb fawb hauv kev tshuaj xyuas cov nroj tsuag metabolomics. Thaum lub sijhawm qee theem kev loj hlob ntawm cov nroj tsuag (kev loj hlob, kev khaws cia txias), cov cell yuav tsim cov kua nplaum uas tsis muaj dej thiab lipids, zoo ib yam li cov khoom sib xyaw ntawm eutectics.

Raws li cov thev naus laus zis sib cais ntsuab niaj hnub, kev siv tshuab membrane sib xyaw ua ke, ua tiav los ntawm kev siv tshuab ultrasonic / microwave txhim kho kom ua tiav qhov kub qis, tsom mus rau, muaj kev txawj ntse siab, zoo thiab ntsuab rho tawm cov khoom xyaw nquag. Los ntawm cov kuab tshuaj supramolecular ntuj ua cov kuab tshuaj rho tawm zoo, nws daws tau ntau yam teeb meem xws li kev ua haujlwm qis, tus nqi siab thiab nyuaj rau kev rov qab cov kua pov tseg ntawm cov tshuaj phytochemical ib txwm muaj. Cov kuab tshuaj supramolecular rho tawm tau raug xaiv rau lawv qhov kev ua tau zoo. Cov kuab tshuaj supramolecular xaiv tau muaj kev ua haujlwm ruaj khov thiab txhim kho kev yaj ntawm cov khoom xyaw nquag, kuj tseem tuaj yeem ua kom zoo dua 20 npaug.

Kev siv tshuab supramolecular synergistic penetration

Cov yam ntxwv kev txawj ntse: Kev lag luam thawj zaug, los ntawm cov tshuaj supramolecular synergistically txhawb kev nkag mus ntawm macromolecules / dej-soluble / nyuaj rau nqus cov khoom xyaw

Cov txiaj ntsig ntawm kev siv tshuab: kev ruaj khov zoo dua, tsis muaj kev puas tsuaj thiab kev nkag mus zoo, kev cuam tshuam synergistic, kev nplua nuj ntawm cov dermis, thiab bioavailability nce 5-7 npaug. Cov khoom xyaw piv txwv: collagen, Bosein, xiav tooj liab peptide, hexapeptide, compound peptide, β-glucan.

Vim tias qhov hnyav molecular ntawm peptide tseem loj dua piv rau lwm cov khoom xyaw nquag, qhov nkag mus rau hauv daim tawv nqaij tsawg heev. Qee qhov kev nkag mus-txhim kho yog qhov xav tau los txhim kho qhov nkag mus-txhim kho cov nyhuv ntawm peptide, yog li ua tiav qhov concentration qis thiab ua haujlwm siab, thiab ua tiav cov txiaj ntsig zoo dua los tiv thaiv kev laus.

Ua teb rau qhov teeb meem ntawm kev lag luam uas tsis nkag mus zoo, hydrophilicity siab thiab bioavailability qis ntawm cov tshuaj macromolecules ib txwm muaj, JUNAS Time Particle cov khoom tsim los ntawm quantum chemistry pab, tuaj yeem ncaj qha mus txog epidermis thiab dermis ntawm daim tawv nqaij los ntawm trans-cellular, intercellular thiab follicular hws ductchannels. Tsis muaj kev puas tsuaj rau cov qauv tawv nqaij. Lub bioavailability ntawm cov khoom tau nce 5 zaug, suav nrog ntau dua 45% hauv dermis, tsis muaj kev puas tsuaj rau cov qauv tawv nqaij. Cov nyhuv nkag mus thiab lub sijhawm nyob tau ua tiav cov kev txhim kho tseem ceeb. Qhov no yog thawj zaug ntawm nws hom hauv kev lag luam.

Kev siv tshuab biocatalysis supramolecular

Bioenzyme-taw qhia catalysis: supramolecular solvents yog siv ua substrates los txhim kho enzyme kev ua ub no, txhim kho chiral xaiv, thiab ua tiav siab purity

Kev tsim cov tshuaj ntsuab fennel fermentation: xaiv cov nroj tsuag yam ntxwv, txhim kho cov ntsiab lus ntawm cov khoom xyaw nquag, cov mis anhydrous, txhim kho qhov ua tau zoo tag nrho

Kev siv tshuab fermentation micellar rov qab: tshuaj xyuas cov yam ntxwv ntawm cov kab mob, fermenting roj zaub, ntau yam teebmeem, txhim kho kev xav ntawm daim tawv nqaij thiab txhim kho kev nqus

Raws li kev siv tshuab recombinant gene, ib kauj ruam gene cloning technology thiab high-density bioenzyme catalytic technology, cov kab mob genetically engineered bacteria yog siv los ua catalytic carriers kom paub txog kev tsim cov tshuaj nquag loj:

Nyob rau hauv lub supramolecular solvent system, cov enzyme qhia tau hais tias muaj kev ua haujlwm siab dua, kev xaiv thiab kev ruaj khov, kev siv cov khoom siv raw substrate ntau dua, kev ua qias tuaj tsawg dua hauv cov txheej txheem ntau lawm, cov xwm txheej tsis tshua muaj zog, kev ua haujlwm nyab xeeb dua thiab kev ua haujlwm ntau lawm.

Kev siv tshuab fermentation rov qab micelle:

Cov roj ntuj xaiv nrog cov yam ntxwv Suav lP tau tsim los ntawm tus kheej los tsim cov surfactants nyob rau hauv qhov kev ua ntawm cov kab mob genetically engineered.lt tau sib sau ua ke ua tus neeg nqa khoom ntawm cov pob khoom tiv thaiv micellar kom paub txog cov pob khoom tiv thaiv micellar ntawm cov khoom xyaw dej-soluble kom ua tiav cov xwm txheej nplua nuj daim ntawv thov, qhov kawg ntawm daim tawv nqaij kev paub, thiab qhov ua tau zoo, kev paub dhau los, thiab qhov ua tau zoo tseem ceeb.

Kev siv tshuab microencapsulation supramolecular

Cov yam ntxwv kev siv tshuab: liposome encapsulation, tsom tso tawm cov hlwb dermal, tsom tso tawm cov plaub hau follicles, thiab teb rau kev tso tawm ntawm cov yam ntxwv inflammatory

Cov Zoo: Nanoization, kev xa khoom meej, kev tso tawm ntev, txo qhov khaus, txhim kho kev ruaj khov, thiab txhawb kev nkag mus tau yooj yim

Piv txwv ntawm cov khoom xyaw: astaxanthin, glabridin, vitamin A, xiav tooj liab peptide, biotin, ceramide, cov roj tseem ceeb ntawm cov nroj tsuag

Cov thev naus laus zis Supramolecular microencapsulation yog raws li liposome, roj emulsion, ionic kua stabilization technology, dermal cell targeted release technology, hair follicle targeted release technology, thiab inflammatory factor responsive release technology. Los ntawm kev tsim cov channel thauj khoom dag, cov khoom tuaj yeem xa cov khoom xyaw nquag kom raug. Nws muaj qhov nrawm zoo heev transdermal nqus, lub sijhawm nyob ntev thiab ruaj khov zoo hauv qhov chaw ntawm daim tawv nqaij. Nws kuj muaj cov nqi qis thiab cov txiaj ntsig zoo hauv kev siv tshuaj pleev ib ce, cov khoom noj khoom haus thiab cov tshuaj.

Peptide hierarchical tus kheej sib dhos thev naus laus zis

Cov yam ntxwv kev siv tshuab: thawj zaug hauv kev lag luam, kev tswj hwm lub hom phiaj ntawm ntau theem ntawm cov amino acid saw thiab polypeptides, cov peptides luv luv uas tau sib sau ua ke, supramolecular polypeptides

Kev taw qhia txog kev siv tshuab: Txhim kho amphiphilicity, txhim kho kev ruaj khov thiab kev tiv thaiv cua sov, txo cov tshuaj lom thiab kev ntxhov siab ntawm lub cev, txhawb kev nqus, thiab sib koom ua ke

Piv txwv ntawm cov khoom xyaw: supramolecular carnosine, poov xab protein peptide

Kev sib sau ua ke ntawm cov protein thiab peptides tsis yog tsuas yog nyob rau hauv lub neej xwb, tab sis kuj yog ib qho khoom zoo heev rau tib neeg lub cev, thiab tseem yog ib qho ntawm cov txheej txheem zoo rau kev tsim cov khoom siv nano-biological. Cov txheej txheem sib sau ua ke ntawm peptide yog cov txheej txheem sib sau ua ke hierarchical, thiab "polar amino acid zipper qauv" yog ib hom tshiab ntawm cov qauv super-secondary, uas yog qhov zoo rau kev sib sau ua ke ntawm peptides los tsim cov khoom sib sau ua ke.

Kev tswj hwm kev taw qhia ntawm qhov loj ntawm cov peptides luv luv tuaj yeem ua tiav los ntawm kev hloov pauv hydrophobicity thiab sab saw branching ntawm hydrophobic residues.

Raws li Shinehigh Innovation lub database tshwj xeeb ProteinDataBank (PDB), ua ke nrog kev soj ntsuam kev sim, kev hloov pauv molecular thiab kev suav lej quantum chemistry los tshuaj xyuas cov qauv ntawm peptide molecules, thiab tom qab ntawd phim lawv nrog cov molecules sib dhos ua ke uas muaj zog heev. Kev hloov pauv ntawm hom, tus lej thiab qhov chaw sib piv ntawm cov amino acids ntawm cov molecules peptide los hloov lawv cov qauv folding tshwj xeeb, yog li txhim kho lub peev xwm ntawm cov molecule los sib dhos ua ke. Paub txog kev tswj hwm lub hom phiaj ntawm peptides. Cov peptide sib dhos ua ke muaj amphiphilicity thiab symmetry zoo heev, uas txhim kho peptide stability, transdermal muaj peev xwm thiab bioavailability zoo heev.